Jason Quigley was stopped by Demetrius Andrade in the second round of their world middleweight title showdown in the early hours of Saturday morning.
The Donegal native came into the fight as the underdog and was on the floor in the first round as Andrade knocked him down with a huge right hook.
Quigley got back up but was down again with just under a minute left in the second round from a thunderous left.
He did well to get back up but the referee stopped the bout moments later when Quigley was knocked down for a third time from a flurry of shots.
The defeat was just the 30-year-old’s second in his career, while Andrade reiterated his desire for a big name fight next as he took his record to 31-0.
Eddie Hearn indicated after the bout that he would like to see Andrade face Jermall Charlo.
Earlier on the card, Thomas O’Toole took his professional record to 2-0 with an impressive first round knockout.
The Galway southpaw stopped Mark Malone midway through the opening round after landing a powerful left hand and following up with a number of punches before the American went down.
O’Toole was supposed to graduate from college on Friday, but instead opted to take the fight on Matchroom’s card in New Hampshire.
Speaking after the win, he told DAZN: “I was meant to graduate from college today and when I got the call for this, you can’t turn it down.
“For the last four years I’ve been thinking about my college graduation. I couldn’t wait to celebrate it but being invited to the biggest stage in boxing was amazing. I’m happy to be here.”
Get the latest sports headlines straight to your inbox by signing up for free email alerts